Publications

Selected Publications

Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans

Collier JJ, Guissart C, Olahova M, Sasorith S, Piron-Prunier F, Suomi F, Zhang D, Martinez-Lopez N, Leboucq N, Bahr A, Azzarello-Burri S, Reich S, Schols L, Polvikoski TM, Meyer P, Larrieu L, Schaefer AM, Alsaif HS, Alyamani S, Zuchner S, Barbosa IA, Deshpande C, Pyle A, Rauch A,Synofzik M, Alkuraya FS, Rivier F, Ryten M, McFarland R, Delahodde A,

McWilliams TG, Koenig M, Taylor RW (2021)

New England Journal of Medicine 384:2406-2417

Basal mitophagy occurs independently of PINK1 in mouse tissues of high-metabolic demand.

McWilliams TG*, Prescott AR, Montava-Garriga L, Brooks SP, Singh F, Barini E,

Muqit MM, Ganley IG* (2018a)

Cell Metabolism Feb 06; 27(2): 439-449. *Corresponding Authors.

Autophagy in the nervous system: a primer for neuroscientists.

Suomi F & McWilliams TG* (2019)

Neuronal Signaling 3 (3): NS20180134. *Senior & Corresponding Author

Mitochondrial DNA can be inherited from fathers, not just mothers.

McWilliams TG* & Suomalainen A* (2019)

Nature 565, 7739, 296-297. *Corresponding Authors

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo.

McWilliams TG*, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar S, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK* (2018b).

Open Biology. Nov 8:180108. *Corresponding Authors

mito-QC illuminates mitophagy and mitochondrial architecture in vivo.

McWilliams TG, Prescott AR, Allen GFG, Tamjar J, Munson MJ, Muqit MMK and Ganley IG (2016)

Journal of Cell Biology Aug 1;214(3):333-45.

_________________________________________________________________________

All Publications

2023

Metabolic set points of mammalian neurodevelopment

Suomi F, Rappe A, McWilliams TG (2023)

Cell Metabolism (In Press)

Fine-tune TMEM11 to unleash basal mitophagy

McWilliams TG (2023)

Journal of Cell Biology (In Press)

Mitochondrial signalling and homeostasis: from cell biology to neurological disease

Collier JJ, Oláhová M, McWilliams TG, Taylor RW (2023)

Trends in Neurosciences Feb;46(2):137-152

Lipid droplets promote efficient mitophagy.

Long M & McWilliams TG* (2023)

Autophagy Feb;19(2):724-725

2022

Mitophagy in the aging nervous system

Rappe A and McWilliams TG* (2022)

Frontiers in Cell and Developmental Biology

10:978142.

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion.

Long, M., Sanchez-Martinez, A., Longo, M., Suomi, F., Stenlund, H., Johansson, A. I., Ehsan, H., Salo, V. T., Montava-Garriga, L., Naddafi, S., Ikonen, E., Ganley, I. G., Whitworth, A. J. and McWilliams, T. G. *

(2022) The EMBO Journal May 16;41(10):e109390.

Mosaic dysfunction of mitophagy in mitochondrial muscle disease.

Mito T, Vincent AE, Faitg J, Taylor RW, Khan NA, McWilliams TG, Suomalainen A (2022)

Cell Metabolism Feb 1;34(2):197-208.e5.

2021

Emerging roles of ATG7 in human health and disease

Collier JJ, Suomi F, Oláhová M, McWilliams TG, Taylor RW (2021)

EMBO Molecular Medicine e14824

Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids

Hamdan F, Ylösmäki E, Chiaro J, Giannoula Y, Long M, Fusciello M, Feola S, Martins B, Feodoroff M, Antignani G, Russo S, Kari O, Lee M, Järvinen P, Nisen H, Kreutzman A, Leusen J, Mustjoki S,

McWilliams TG, Grönholm M, Cerullo V (2021)

Journal for ImmunoTherapy of Cancer Aug;9(8):e003000.

ATG7 safeguards neural integrity

Collier JJ, Olahova M, McWilliams TG, Taylor RW (2021)

Autophagy (Jul 27: 1-3 - In Press).

Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans

Collier JJ, Guissart C, Olahova M, Sasorith S, Piron-Prunier F, Suomi F, Zhang D, Martinez-Lopez N, Leboucq N, Bahr A, Azzarello-Burri S, Reich S, Schols L, Polvikoski TM, Meyer P, Larrieu L, Schaefer AM, Alsaif HS, Alyamani S, Zuchner S, Barbosa IA, Deshpande C, Pyle A, Rauch A,Synofzik M, Alkuraya FS, Rivier F, Ryten M, McFarland R, Delahodde A,

McWilliams TG, Koenig M, Taylor RW (2021)

New England Journal of Medicine 384:2406-2417

Reply to Liu et al.

Ganley IG*, Whitworth AJ* and McWilliams TG* (2021)

Autophagy Apr (5): 1-3

Guidelines for the use and interpretation of assays for monitoring autophagy, 4th Edition.

Klionsky et al., (Global Autophagy Community including McWilliams TG) (2021)

Autophagy Jan 17;(1) 1-382.

2019

Fate of a father’s mitochondria.

McWilliams TG* & Suomalainen A* (2019)

Nature 565, 7739, 296-297. *Co-corresponding Authors

Investigating Mitophagy and Mitochondrial Morphology In Vivo Using mito-QC: A Comprehensive Guide

McWilliams TG and Ganley IG (2019)

Methods in Molecular Biology: Autophagy 1880:621-642

CD40 forward signalling is a physiological regulator of early sensory axon growth

Howard L, McWilliams TG, Wyatt S and Davies AM (2019)

Development 146, 18

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams TG, Prescott AR, Villarejo-Zori B, Ball G, Boya P, Ganley IG (2019)

Autophagy 15 (7): 1296–1308

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Muha V, Williamson R, Hills R, McNeilly AD, McWilliams TG, Alonso J, Schimpl M, Leney AC, Heck AJR, Sutherland C, Read KD, McCrimmin RJ, Brooks SP, van Aalten DMF (2019)

Open Biology 93, 487-504.

PGC-1β modulates statin-associated myotoxicity in mice

Singh F, Zoll J, Duthaler U, Charles AL, Panajatovic MV, Laverny G, McWilliams TG, Metzger D, Geny B, Krähenbühl S (2019)

Archives of Toxicology 93, 487-504.

Autophagy in the nervous system: a primer for neuroscientists.

Suomi F & McWilliams TG* (2019)

Neuronal Signaling 3 (3): NS20180134. *Senior & Corresponding Author

Monitoring autophagy in cancer: from bench to bedside.

Long M & McWilliams TG* (2019)

Seminars in Cancer Biology *Senior & Corresponding Author

2018

Basal mitophagy occurs independently of PINK1 in mouse tissues of high-metabolic demand.

McWilliams TG*, Prescott AR, Montava-Garriga L, Brooks SP, Singh F, Barini E, Muqit MM and Ganley IG* (2018a)

Cell Metabolism Feb 06; 27(2): 439-449.

*Corresponding Authors

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo.

McWilliams TG*, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar S, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK* (2018b).

Open Biology. Nov 8:180108.

*Corresponding Authors

2017

TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo

McWilliams TG, Howard L, Wyatt S and Davies AM (2017)

Experimental Neurology 298, 97-103.

PINK1 and Parkin: Emerging themes in mitochondrial homeostasis.

McWilliams TG & Muqit MMK (2017)

Current Opinion in Cell Biology. Vol. 45 “Special Edition on Cell Regulation”. 83-91.

Mammalian Mitophagy: From In Vitro Molecules to In Vivo Models.

Rodger C, McWilliams TG, Ganley IG (2017)

The FEBS Journal Apr;285(7):1185-1202. Open Access.